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Latest research 19 Aug 2015

Pregnancy after breast cancer trial

Although not everyone will have children, most people want to at least have the choice. Cancer and treatment for cancer can sometimes make this harder or even take away this option. Some breast cancer treatments, such as certain chemotherapy drugs, may affect a woman’s ability to have a baby (fertility). Still, many women are able to become pregnant after treatment.

The POSITIVE trial (open November 2015) will be Western Australian (WA) based for women wanting to become pregnant after breast cancer. They will be recruiting young women with oestrogen receptor positive (ER+) breast cancer who wish to interrupt hormone therapy (tamoxifen) to attempt to conceive a baby. The trial is only available at St John of God Hospital, Subiaco, Western Australia, but will recruit young women from around WA.

The POSITIVE trial is currently enrolling women who meet the following criteria:

  • Aged 18 to 42
  • Have received adjuvant hormone therapy for 18-30 months for early breast cancer
  • Wish to become pregnant

The study involves the interruption of hormone treatment for 2 years in order to attempt pregnancy.

Participation will involve brief 3-monthly clinic visits, blood samples that are collected at 3, 6 and 12 months, and a pelvic ultrasound performed at 3 and 6 months. There are also some optional questionnaires the researchers would like you to complete.

Note: Funding for this research comes from a number of sources including the Cancer Council WA, NHMRC and the State government.

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